TY  - BOOK
AU  - Hofrichter, Jacqueline
PY  - 2014
DA  - 2014//
TI  - influence of plant  extracts on β-Amyloid induced pathologies in an APP/PS1 mouse model of Alzheimer's disease
PB  - Universität Rostock
CY  - Rostock
AB  - The study explored the influence of plant extracts on neuronal degeneration caused by toxic β-amyloid in a transgenic APP/PS1 mouse model of Alzheimer‘s disease. Daily oral application of extracts of Hypericum perforatum and Sideritis spp. attenuated Aβ-induced histopathology and alleviated memory impairments in APP/PS1 mice. In detail, both extracts (i) decreased intracerebral Aβ42 and (ii) Aβ plaques, (iii) rescued neocortical neurons, and (iv) restored cognition to healthy control levels due to an enhanced Aβ42 export activity of ABCC1 and an increased phagocytic microglia activity.<eng>
UR  - http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2016-0083-8
LA  - English
N1  - vorgelegt von: Jacqueline Hofrichter
ID  - 865502897
ER  -