TY  - BOOK
AU  - Haack, Fiete
PY  - 2015
DA  - 2015//
TI  - Exploring the spatio-temporal dynamics of lipid rafts and their role in signal transduction: a modeling and simulation approach
PB  - Universität Rostock
CY  - Rostock
AB  - The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach.<eng>
UR  - http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2016-0080-1
LA  - English
N1  - vorgelegt von: Fiete Haack aus Rostock
ID  - 865456275
ER  -