TY  - BOOK
AU  - Salem, Tareq
PY  - 2014
DA  - 2014//
TI  - Gene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancer
AB  - This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0174-3
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0174-3&pdf
UR  - http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0174-3
LA  - English
N1  - submitted by Tareq Salem
ID  - 805590951
ER  -