TY  - BOOK
AU  - Mani, Jiju
PY  - 2014
DA  - 2014//
TI  - CD8+ T cell epitopes derived from the polyomavirus capsid protein VP 1
AB  - One method for treatment of JCV and BKV-related diseases is by adoptive transfer of virus-specific T-cells. Precursor frequency of JCV-capsid protein VP1-specific T-cells was very low compared to other viruses. Optimized assays revealed JCV-specific T cells with high avidity, peptide-specificity and high functional reactivity in long-term cultures. Additionally, novel, naturally processed JCV-VP1-derived CD8+ T cell epitopes were identified. These new data contribute to the development of therapies that, due to their cross-reactivity, target both polyomaviruses-related diseases simultaneously.
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0101-6
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0101-6&pdf
UR  - http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0101-6
LA  - English
N1  - submitted [by] Jiju Mani
ID  - 793013402
ER  -