TY  - BOOK
AU  - Supe, Linda
PY  - 2014
DA  - 2014//
TI  - Design and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosides: new purine isosters as potential drug-like scaffolds
AB  - The work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues were synthesized using modified silyl Hilbert-Jones method. Scope and limitations of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied.
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0102-2
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0102-2&pdf
UR  - http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0102-2
LA  - English
N1  - vorgelegt von Linda Supe
ID  - 791606627
ER  -