TY  - BOOK
AU  - Lao, Angelyn
PY  - 2012
DA  - 2012//
TI  - systems biology approach to understand the influence of SORLA on amyloidogenic processing in Alzheimer's disease
AB  - In this dissertation APP processing is modelled and the influence of SORLA in Alzheimer’s disease is evaluated. A model with both monomeric and dimeric APP in a single compartment best fitted the experimental data suggesting that SORLA prevents APP oligomerization and affects β-secretase indirectly. Including compartmental details into the combined model, the multi-compartmental model determines the relative contribution of SORLA to each APP-cleavage step showing that SORLA specifically impairs the processing of APP dimer and alters the dynamical behavior of beta-secretase.
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0075-4
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0075-4&pdf
UR  - http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0075-4
LA  - English
N1  - vorgelegt von Angelyn Lao
ID  - 782499139
ER  -