TY  - BOOK
AU  - Schmitz, Yvonne
PY  - 2013
DA  - 2013//
TI  - Compartmental modelling of the Wnt pathway: elucidating the role of nucleo-cytoplasmic shuttling of β-catenin and its antagonists
AB  - The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0055-2
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0055-2&pdf
UR  - http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0055-2
LA  - English
N1  - vorgelegt von Yvonne Schmitz
ID  - 779622480
ER  -