TY  - BOOK
AU  - Mazemondet, Orianne
PY  - 2011
DA  - 2011//
TI  - Spatio-temporal dynamics of the Wnt/β-catenin signaling pathway: a computational systems biology approach
AB  - The Wnt/ß-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. We show the importance of stochastic approach and suggest further experiments, hence closing the computational systems biology loop.
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2012-0005-4
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2012-0005-4&pdf
UR  - http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2012-0005-4
LA  - English
N1  - vorgelegt von Orianne Mazemondet
ID  - 684559005
ER  -