TY  - BOOK
AU  - Liu, Shuzhen
PY  - 2009
DA  - 2009//
TI  - role of NF-kB and C/EBP factors during pathogen-mediated activation of bovine interleukin 8 and beta-defensin in mammary epithelial cells
AB  - Molecular mechanisms of pathogen-induced activation of the IL-8 and LAP genes were investigated in Mammary Epithelial Cells. Activity of the resting IL-8 promoter is inhibited by NF-kappaB p65, but activated quickly after pathogen contact by C/EBP factors. Conversely, NF-kappaB p65 drives LAP expression some time after pathogen induction, while C/EBP factors attenuate activity of this promoter. Hence, in the very same cell type NF-kappaB p65 and C/EBP factors antagonistically regulate both immune relevant genes before and after pathogen mediated stimulation.
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0185-5
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0185-5&pdf
UR  - http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0185-5
UR  - http://d-nb.info/101425678X/34
UR  - http://rosdok.uni-rostock.de/file/rosdok_derivate_000000004087/Dissertation_Liu_2009.pdf
LA  - English
N1  - by Shuzhen Liu
ID  - 65676662X
ER  -