TY - BOOK AU - Bader, Benjamin M. PY - 2010 DA - 2010// TI - Spatio-temporal control of Wnt/β-catenin signaling during fate commitment of human neural progenitor cells AB - The Wnt/beta-catenin pathway is involved in neural stem cell self-renewal and neuronal differentiation. Further understanding of these processes is a prerequisite of cell replacement therapies in neurodegenerative diseases such as Parkinson's disease. In this context, the role of Wnt/beta-catenin signaling was studied in this thesis which substantiates the presently limited knowledge about neurogenesis in human cell models and shows parallels between the mechanistic knowledge based on rodent models and the use of human neural stem cells for cell replacement strategies in neurodegenerative diseases. UR - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2010-0135-6 UR - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2010-0135-6&pdf UR - http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2010-0135-6 UR - http://d-nb.info/1010575481/34 UR - http://rosdok.uni-rostock.de/metadata/rosdok_disshab_000000000502 LA - English N1 - vorgelegt von: Benjamin M. Bader ID - 639568327 ER -