TY  - BOOK
AU  - Schwarz, Nicolle
PY  - 2008
DA  - 2008//
TI  - Synthesis and catalytic functionalization of biologically active indoles
AB  - Of fundamental importance in nature are substituted indoles. The thesis presents the synthesis of new indole derivatives and their functionalization to potential 5-HT6 receptor ligands. Based on our prior synthesis to indole analogues we investigated a synthetic strategy to innovative indole scaffolds via Ti- or Zn-catalyzed hydrohydrazination of terminal alkynes. We developed the pharmaceutical interesting class of 3-silyloxyindoles and their further application in several catalytic reactions. Buchwald-Hartwig amination, C-O cross- coupling and sulfonylation were utilized and optimized.
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0035-0
UR  - http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0035-0&pdf
UR  - http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0035-0
LA  - English
N1  - vorgelegt von Nicolle Schwarz
ID  - 59268413X
ER  -