TY  - BOOK
AU  - Dai, Meng
PY  - 2026
DA  - 2026//
TI  - Establishment of preclinical tumor models for colorectal cancer precision medicine
PB  - Universität Rostock
CY  - Germany; Rostock
AB  - Colorectal cancer (CRC) is the third most prevalent and second deadliest cancer worldwide. This prospective cohort study established patient-derived CRC organoids (75% success rate) and tumor-infiltrating lymphocytes (TILs, 87.5% success rate) as preclinical models for therapy prediction. Targeted NGS sequencing revealed TP53, APC, and KRAS as the most frequent mutations; MSI was detected in 11% of patients. Organoid-TIL co-culture enables exploration of the tumor microenvironment and immune evasion mechanisms, supporting personalized immunotherapy strategies.<eng>
UR  - https://purl.uni-rostock.de/rosdok/id00005813
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00005813-8
UR  - https://d-nb.info/1420686658/34
UR  - https://doi.org/10.18453/rosdok_id00005813
DO  - 10.18453/rosdok_id00005813
LA  - English
N1  - vorgelegt von Meng Dai
ID  - 1985138166
ER  -