TY  - BOOK
AU  - Su, Zhaoran
PY  - 2025
DA  - 2025//
TI  - NAALADL1 as a key modulator of resistance to Tumor Treating Fields therapy in colorectal cancer
PB  - Universität Rostock
CY  - Germany; Rostock
AB  - Colorectal cancer (CRC) shows heterogeneous responses to Tumor Treating Fields (TTF), a non-invasive therapy disrupting mitosis. In 21 CRC cell lines, TTF induced microtubule disruption, mitotic defects, metabolic stress, DNA damage, and apoptosis. NAALADL1 was upregulated in resistant cells; its knockdown enhanced TTF sensitivity by stabilizing microtubules and inducing G2/M arrest. Virtual screening identified Lumacaftor and Bestatin as synergistic with TTF, highlighting NAALADL1 as a promising target for personalized CRC therapy.<eng>
UR  - https://purl.uni-rostock.de/rosdok/id00005800
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00005800-2
UR  - https://d-nb.info/1420686534/34
UR  - https://doi.org/10.18453/rosdok_id00005800
DO  - 10.18453/rosdok_id00005800
LA  - English
N1  - vorgelegt von Zhaoran Su
ID  - 1984314068
ER  -