TY  - BOOK
AU  - Agrifoglio, Ottavia
PY  - 2025
DA  - 2025//
TI  - Metabolic alterations and early development of sarcopenia in a murine model of cholestatic liver disease
PB  - Universität Rostock
CY  - Germany; Rostock
AB  - A murine bile duct ligation (BDL) model was used to study molecular mechanisms of sarcopenia and malnutrition in cholestatic liver disease. C57BL/6J mice randomly underwent a BDL or Sham surgery or were used as controls. Metabolism, inflammatory markers, fractional protein synthesis rate, muscle function and gene expression were assessed. Sarcopenia occurs early, and involves systemic inflammation, a catabolic state, reduced protein synthesis and degradation of muscle proteins. Malnutrition and sarcopenia are present in parallel in, and that they trigger each other in a sort of vicious circle.<eng>
UR  - https://purl.uni-rostock.de/rosdok/id00005753
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00005753-8
UR  - https://d-nb.info/1416682082/34
UR  - https://doi.org/10.18453/rosdok_id00005753
DO  - 10.18453/rosdok_id00005753
LA  - English
N1  - vorgelegt von Ottavia Agrifoglio
ID  - 1981805737
ER  -