TY  - BOOK
AU  - Dhar, Prabir
PY  - 2025
DA  - 2025//
TI  - E2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanoma
PB  - Universität Rostock
CY  - Germany; Rostock
AB  - In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.<eng>
UR  - https://purl.uni-rostock.de/rosdok/id00005667
UR  - https://doi.org/10.18453/rosdok_id00005667
DO  - 10.18453/rosdok_id00005667
LA  - English
N1  - vorgelegt von Prabir Dhar
ID  - 1979689067
ER  -