TY  - BOOK
AU  - Salti, Haitham
PY  - 2024
DA  - 2024//
TI  - Establishment of a human 3D kidney tissue model using decellularized rat kidney slices
PB  - Universität Rostock
CY  - Rostock
AB  - This study explores physical pretreatments to improve kidney decellularization, addressing the need for a bioartificial kidney as an alternative treatment for end-stage renal disease. Freezing-thawing cycles (FTC) and high hydrostatic pressure (HHP) were compared to chemical decellularization. FTC was the most effective in removing DNA and preserving the extracellular matrix (ECM), and showed better scaffold recellularization with kidney cells. Analysis with artificial intelligence revealed insights into the instructive memory of the ECM, guiding cells to avoid attachment to nonspecific sites.<eng>
UR  - https://purl.uni-rostock.de/rosdok/id00005005
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00005005-3
UR  - https://d-nb.info/1382476930/34
UR  - https://doi.org/10.18453/rosdok_id00005005
DO  - 10.18453/rosdok_id00005005
LA  - English
N1  - vorgelegt von Haitham Salti
ID  - 194143438X
ER  -