TY  - BOOK
AU  - Saleem, Kanza
PY  - 2023
DA  - 2023//
TI  - Loss-Of HSPB8 leads to prolonged stress granules disassembly via impaired CASA-complex ultimately causing FUS-aggregation
PB  - Universität Rostock
CY  - Rostock
AB  - Our research sheds light on the collaborative functioning of various chaperone systems within the proteostasis network. Molecular chaperones, including HSP70, and HSP40, and co-chaperones like HSC70, HSP90, and CHIP, are vital in protein quality control and degradation. Dysregulation within these systems, observed in HSPB8 knockout neurons, indicates impaired mechanisms for maintaining cellular proteostasis. This deficiency renders cells vulnerable to stress, resulting in detrimental effects on cellular survival.<eng>
UR  - https://purl.uni-rostock.de/rosdok/id00004622
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004622-9
UR  - https://d-nb.info/1334986673/34
UR  - https://doi.org/10.18453/rosdok_id00004622
DO  - 10.18453/rosdok_id00004622
LA  - English
N1  - vorgelegt von Kanza Saleem
ID  - 189282163X
ER  -