TY  - BOOK
AU  - Müller-Eigner, Annika
PY  - 2023
DA  - 2023//
TI  - Assessing the impact of sodium butyrate and a light-activated proton pump on energy metabolism and lifespan of Drosophila melanogaster and Caenorhabditis elegans
PB  - Universität Rostock
CY  - Rostock
AB  - In this thesis, the impact of sodium butyrate (SB) on mitochondrial and metabolic function and lifespan was investigated. SB treatment showed a rapid and transient increase in oxygen consumption in fly heads. Mass spectrometry analysis revealed incorporation of labeled SB into mitochondrial pathway metabolites. An SB-independent way for mitochondrial activation was assessed in this work. The mitochondrial membrane potential of C. elegans was increased, using a light-activated proton pump, resulting in an extended median lifespan, even if the intervention took part in mid- or late-staged worms.<eng>
UR  - https://purl.uni-rostock.de/rosdok/id00004576
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004576-2
UR  - https://d-nb.info/1329239512/34
UR  - https://doi.org/10.18453/rosdok_id00004576
DO  - 10.18453/rosdok_id00004576
LA  - English
N1  - vorgelegt von Annika Müller-Eigner
ID  - 1887560912
ER  -