TY  - BOOK
AU  - Sueto, Salem Oduro Beffi
PY  - 2023
DA  - 2023//
TI  - Microarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interaction
PB  - Universität Rostock
CY  - Rostock
AB  - The present work uses transcriptomics data from the microarray platform to study the biological imprint of Hutchinson-Gilford progeria syndrome and other senescence processes such as telomere elongation. Literature review of drug repurposing analysis was conducted to find tools that use transcriptomics data as input. RNA-seq technology was used to simultaneously study the gene expression of both the host (human) and the pathogen (S. pyogenes and Influenza A virus). The host expression was used as input for drug repurposing analysis to identify potential drugs for anti-infective treatment.<eng>
UR  - https://purl.uni-rostock.de/rosdok/id00004514
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004514-9
UR  - https://d-nb.info/1315379406/34
UR  - https://doi.org/10.18453/rosdok_id00004514
DO  - 10.18453/rosdok_id00004514
LA  - English
N1  - vorgelegt von Salem Odura Beffi Sueto
ID  - 1877357669
ER  -