TY  - BOOK
AU  - Abt-Becker, Corina
PY  - 2023
DA  - 2023//
TI  - antimicrobial activity of carrier-coupled antisense peptide nucleic acids (PNAs) on streptococci
PB  - Universität Rostock
CY  - Rostock
AB  - The pathogens Streptococcus pneumoniae and Streptococcus pyogenes can cause serious diseases. In this work effective carrier-coupled antisense peptide nucleic acids (PNAs) against S. pneumoniae were identified. The counteranion pyrenebutyrate was investigated for its ability to improve uptake of CPP-PNAs in streptococci. Furthermore, transcriptomic effects of CPP-PNA on streptococci were examined. As Galleria mellonella is an increasingly popular infection model organism, additionally the S. pyogenes specific immune response of the larvae was investigated using a proteomics approach.<eng>
UR  - https://purl.uni-rostock.de/rosdok/id00004509
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004509-4
UR  - https://d-nb.info/131537935X/34
UR  - https://doi.org/10.18453/rosdok_id00004509
DO  - 10.18453/rosdok_id00004509
LA  - English
N1  - vorgelegt von Corina Abt-Becker
ID  - 1877132748
ER  -