TY  - BOOK
AU  - Salewski, Inken
PY  - 2023
DA  - 2023//
TI  - Combined immunotherapy approaches in preclinical models of mismatch-repair-deficiency-associated tumorigenesis
PB  - Universität Rostock
CY  - Rostock
AB  - In this thesis, different immunotherapy strategies we employed to combat mismatch-repair-deficient (dMMR) cancer. We used two preclinical mouse models, either having constitutional (Mlh1) or conditional (Msh2) knock out. To prevent resistance development and improve outcome, we focused on combination strategies including whole tumor vaccines, immune checkpoint-inhibitors (α-PD-L1), classical chemotherapy or the Cyclin-dependent kinase inhibitor abemaciclib. By applying different combination strategies, a significant survival benefit was reached in all investigated treatments.<eng>
UR  - http://purl.uni-rostock.de/rosdok/id00004407
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004407-6
UR  - https://d-nb.info/1301016535/34
UR  - https://doi.org/10.18453/rosdok_id00004407
DO  - 10.18453/rosdok_id00004407
LA  - English
N1  - vorgelegt von Inken Salewski
ID  - 1857757386
ER  -