TY  - BOOK
AU  - Ma, Yixuan
PY  - 2022
DA  - 2022//
TI  - Characterization of pathway specific inhibitor response in pancreatic ductal adenocarcinoma in vitro models with different genetic backgrounds
PB  - Universität Rostock
CY  - Rostock
AB  - Key proteins such as CK2, CDK, PI3K, AKT and KRAS are often considered as promising target molecules for therapeutic intervention strategies due to their important roles in the occurrence, development and prognosis of PDAC. The aim of this doctoral thesis was to explore the different effects of the above-mentioned key protein inhibitors on various PDAC cell lines, and to explore the effect of aberrations in the target genes of the inhibitors on the efficacy of the corresponding inhibitors by applying whole-exome sequencing (WES) and RNA sequencing (RNA-seq).<eng>
UR  - http://purl.uni-rostock.de/rosdok/id00004330
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004330-3
UR  - https://d-nb.info/1297582942/34
UR  - https://doi.org/10.18453/rosdok_id00004330
DO  - 10.18453/rosdok_id00004330
LA  - English
N1  - vorgelegt von Yixuan Ma
ID  - 1851554688
ER  -