TY  - BOOK
AU  - Yang, Fan
PY  - 2019
DA  - 2019//
TI  - Defective myelination and its relative mechanism in Niemann-Pick type C disease
PB  - Universität Rostock
CY  - Rostock
AB  - Niemann-Pick type C (NPC) disease is caused by mutations in npc1 or npc2 gene. In this study, we found the maturation of NPC1-/- oligodendrocytes was significantly inhibited, the myelin-related transcription factors Olig1 and Olig2 were downregulated and the nucleocytoplasmic transport of p57Kip2 was inhibited in NPC1-/- oligodendrocytes. Treatment of lovastatin reduced accumulation of cholesterol in the late endosomal and lysosomal, increased the expression of Olig1 and Olig2, recovered the nucleocytoplasmic transport of p57Kip2, and restored the maturation of NPC1-/- oligodendrocytes.<eng>
UR  - http://purl.uni-rostock.de/rosdok/id00003713
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003713-9
UR  - https://d-nb.info/1293537683/34
UR  - https://doi.org/10.18453/rosdok_id00003713
DO  - 10.18453/rosdok_id00003713
LA  - English
N1  - vorgelegt von Fan Yang
ID  - 1807555275
ER  -