TY  - BOOK
AU  - Butenko, Konstantin
PY  - 2021
DA  - 2021//
TI  - Modeling perspective on translatability of deep brain stimulation mechanism for treating Parkinsonian motor symptoms in rodent and human
PB  - Universität Rostock
CY  - Rostock
AB  - Deep brain stimulation is an established treatment for Parkinson’s disease (PD). However, to advance its effectiveness, researchers need to gain a better understanding of the action mechanism by means of in vivo and in silico studies. This thesis presents neural activation patterns theoretically beneficial for motor improvement in PD and analyzes their theoretical reproducibility in a rat brain. Besides, it elucidates biophysical and computational problems to be addressed in order to optimize animal studies and avoid misconceptions when transferring experimental findings to clinical trials.<eng>
UR  - http://purl.uni-rostock.de/rosdok/id00003623
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003623-9
UR  - https://d-nb.info/1293537381/34
UR  - https://doi.org/10.18453/rosdok_id00003623
DO  - 10.18453/rosdok_id00003623
LA  - English
N1  - vorgelegt von Konstantin Butenko
ID  - 1799953491
ER  -