TY  - BOOK
AU  - Shang, Yuru
PY  - 2021
DA  - 2021//
TI  - Immunoglobulin G mediates chemoresistance to oxaliplatin in colon cancer cells by inhibiting the ERK signal transduction pathway
PB  - Universität Rostock
CY  - Rostock
AB  - The aim of this study was to investigate the effect of therapeutically used immunoglobulin G (IgG) on colon cancer in the presence of oxaliplatin. We observed that IgG failed to significantly influence tumor cell viability and tumor growth; however, it significantly inhibited the cytotoxic activity of oxaliplatin in vitro. In addition, we observed that oxaliplatin-induced the activation of ERK; however, IgG inhibits ERK activity. This implies that the application of therapeutical IgG to treating patients, which are receiving oxaliplatin, might have harmful side effects.<eng>
UR  - http://purl.uni-rostock.de/rosdok/id00003037
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003037-4
UR  - https://d-nb.info/1293663751/34
UR  - https://doi.org/10.18453/rosdok_id00003037
DO  - 10.18453/rosdok_id00003037
LA  - English
N1  - vorgelegt von Yuru Shang
ID  - 1759758876
ER  -