TY  - BOOK
AU  - Schwartz, Margit
PY  - 2018
DA  - 2018//
TI  - Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cells: role of the anti-oxidative enzyme heme oxygenase-1
PB  - Universität Rostock
CY  - Rostock
AB  - Excessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects  via an HO-1-independent mechanism.<eng>
UR  - http://purl.uni-rostock.de/rosdok/id00002522
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00002522-0
UR  - https://d-nb.info/1293657557/34
UR  - https://doi.org/10.18453/rosdok_id00002522
DO  - 10.18453/rosdok_id00002522
LA  - English
N1  - vorgelegt von Margit Schwartz
ID  - 167175865X
ER  -