TY  - BOOK
AU  - Voronina, Natalia
PY  - 2016
DA  - 2016//
TI  - Production and characterization of genetically modified magnetized cells for future targeted treatment of cardiovascular diseases
PB  - Universität Rostock
CY  - Rostock
AB  - Gene therapy is a promising tool for cardiovascular disease treatment. Its wide clinical application is, however, limited by the lack of suitable targeted gene delivery systems. In this work, a non-viral vector was tested - composed by polyethyleneimine and magnetic nanoparticles (PEI/MNP) - with primary endothelial cells as in vitro model for angiogenesis and CD133+ hematopoietic stem cells. The obtained results indicate that transient genetic modification of cells with miRNA delivered by PEI/MNP is feasible and results in their magnetization sufficient for targeting and MRI detection.<eng>
UR  - http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2018-0050-4
UR  - https://nbn-resolving.org/urn:nbn:de:gbv:28-diss2018-0050-4
UR  - https://d-nb.info/1293652040/34
UR  - https://doi.org/10.18453/rosdok_id00002056
DO  - 10.18453/rosdok_id00002056
LA  - English
N1  - submitted by Natalia Voronina
ID  - 1018502297
ER  -