TY  - BOOK
AU  - Pügge, Johanna
PY  - 2016
DA  - 2016//
TI  - Adhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculation
PB  - Universität Rostock
CY  - Rostock
AB  - Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. Histones type 3 were given locally to the cremaster muscle sack and specific adhesion molecules were blocked by systemic administration of monoclonal antibodies. Extracellular histones 3 induced leukocyte recruitment in a dose-dependent manner. Histone-induced neutrophil rolling is predominately mediated by P-selectin/PSGL-1 interactions, whereas histone-induced leukocyte adhesion is inter alia mediated by Mac-1 and LFA-1.<eng>
UR  - http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2017-0168-6
LA  - English
N1  - vorgelegt von Johanna Pügge
ID  - 1009595563
ER  -