Wnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathway
Wnt/[beta]-catenin
Talabattula, Venkata Ajay Narendra
1982-
VerfasserIn
aut
Rolfs, Arndt
1959-
GutachterIn
oth
Rune, Gabriele M.
1954-
GutachterIn
oth
Murua Escobar, Hugo
GutachterIn
oth
Universität Rostock
Grad verleihende Institution
dgg
Universitätsmedizin Rostock
Grad verleihende Institution
dgg
text
theses
Text
Hochschulschrift
gw
2015
monographic
XA-DE
Rostock
Universität
publisher
2015
eng
1 Online-Ressource
HumanNPCs (hNPCs) are the suitable cell source in translation medicine for neurodegenerative disease. In the present study, effects of Wnt3a on the differentiation of hNPC were studied. The results showed that Wnt3a induces canonical and non canonical Wnt pathways. Furthermore, Wnt3a increases Ca2+ target genes CaMKII and Pyk2 in the differentiating VM cells. The results demonstrated that Pyk2 decreases GSK3β activity and stabilizes β-catenin, suggesting there is an intercross between Wnt/β-catenin and Wnt/Ca2+-pathway via Pyk2.<eng>
vorgelegt von Venkata Ajay Narendra Talabattula
Dissertation Universität Rostock 2017
610
http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2017-0048-9
Wnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathway
Rostock : Universität, 2015
Druck-Ausgabe
(DE-627)884391353
Talabattula, Venkata Ajay Narendra, 1982 -
urn:nbn:de:gbv:28-diss2017-0048-9
982657090
rda
DE-627
170418
884550958
20251224T204457.0
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