The
role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cells
Lemcke, Heiko
1982-
aut
text
theses
Text
Hochschulschrift
gw
2013
monographic
XA-DE
2013
eng
text/html
application/pdf
Online-Ressource Ill., graph. Darst.
Our findings provide a dual function of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the neural development of human progenitor cells. 1) GJIC accompanied by high Cx43 expression is necessary to maintain cells in a proliferative state by mediating the mitogenic effects of growth factors. 2) GJIC is required to complete neuronal differentiation, including the establishment of a neural network. However, uncoupling of cells is crucial in the early stage of differentiation during cell fate commitment. Further, we showed that Cx43 regulates neuronal cell-fate.
eingereicht von Heiko Lemcke
Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2013
610
WE 2600
42.23
44.90
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2015-0007-1
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2015-0007-1&pdf
http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2015-0007-1
The role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cells
2013
(DE-627)78215073X
Lemcke, Heiko, 1982 -
urn:nbn:de:gbv:28-diss2015-0007-1
935806720
rakwb
DE-627
150209
817694552
20230427T152218.0
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