Gene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancer
Salem, Tareq
1970-
aut
text
theses
Text
Hochschulschrift
gw
2014
monographic
XA-DE
2014
eng
text/html
application/pdf
Online-Ressource Ill., graph. Darst.
This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.
submitted by Tareq Salem
Rostock, Univ., Med. Fak., Diss., 2014
610
44.81
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0174-3
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0174-3&pdf
http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0174-3
Gene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancer
2014
(DE-627)799256013
Salem, Tareq, 1970 -
urn:nbn:de:gbv:28-diss2014-0174-3
935761205
rakwb
DE-627
141126
805590951
20230428T004448.0
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