Role of HCN channels in regulation of synaptic plasticity at early postnatal medial perforant path
Guli, Xiati
1985-
aut
text
theses
Text
Hochschulschrift
gw
2013
monographic
XA-DE
2013
eng
text/html
application/pdf
Online-Ressource Ill., graph. Darst.
HCN channel blocker ZD7288 depressed synaptic transmission at medial perforant path (MPP) synapses. Low-frequency stimulation (LFS) delivered to these fibers resulted in enhanced LTD after ZD7288 in P9-15 rats, but not in P30-60 rats. Hence, HCN channel activation during neuronal activity may compromise the propensity of LTD at these synapses. Results obtained with L-NAME iterated the effect of HCN channel inhibition on LTD, suggesting that retrograde signaling with NO might play a major role in the linkage between postsynaptic NMDAR activation and presynaptic HCN channel function.
submitted by : Badel[,] Gulshat (Guli Xiati)
Rostock, Univ., Med. Fak., Diss., 2013
610
44.37
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0064-2
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0064-2&pdf
http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0064-2
Role of HCN channels in regulation of synaptic plasticity at early postnatal medial perforant path
2013
(DE-627)779620968
Guli, Xiati, 1985 -
urn:nbn:de:gbv:28-diss2014-0064-2
935375118
rakwb
DE-627
140402
782236049
20230426T082527.0
Converted from MARCXML to MODS version 3.8 using MARC21slim2MODS3-8_XSLT1-0.xsl
(Revision 1.174 20250328)
ger