Identification of host cellular requirements for positive strand RNA viruses
Hepatitis C virus and hepatits E virus
John, Lijo
1979-
aut
text
theses
Text
Hochschulschrift
gw
2011
monographic
XA-DE
2011
eng
text/html
application/pdf
Online-Ressource Ill., graph. Darst.
Investigation of the host cellular requirements of two positive strand RNA viruses, by microarray, phospho-proteome array and by siRNA screening identified differential expression of host genes during hepatitis C virus viral entry. Also my studies suggest that NS4B regulates a newly identified oncogenic pathway. For hepatitis E virus, I looked for the cellular effects conferred by the capsid protein ORF2, and the results showed that ORF2 induced activation of CHOP did not lead to apoptosis which might be due to the up regulation of anti-apoptotic chaperones like Hsp72.
vorgelegt von Lijo John
Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2011
570
570
44.43
42.13
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2013-0159-8
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2013-0159-8&pdf
http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2013-0159-8
Identification of host cellular requirements for positive strand RNA viruses
2011
Druck-Ausgabe
(DE-627)671903756
John, Lijo, 1979 -
urn:nbn:de:gbv:28-diss2013-0159-8
935175524
rakwb
DE-627
131128
772571481
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