Novel small molecules as GSK-3β inhibitors in human neural progenitor cells
GSK-3[beta]
Schmöle, Anne-Caroline
1983-
aut
text
theses
Text
Hochschulschrift
gw
2010
monographic
XA-DE
2010
eng
text/html
application/pdf
Online-Ressource graph. Darst.
GSK-3ß as the key enzyme of Wnt/ß-catenin pathway is involved in various processes during the neuronal differentiation of stem and progenitor cells. Therefore small molecules are of great interest as they might provide new pharmacological tools to influence and study underlying mechanism. Thus, we developed a multi-level screening system to identify novel GSK-3ß inhibitors. The influence on Wnt/ß-catenin signaling was evaluated in human neural progenitor cells. New compounds raised the neuronal differentiation, whereat it was shown that the effect was due antagonistic action at GSK-3ß.
vorgelegt von Anne-Caroline Schmöle
Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2011
44.90
44.37
42.13
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0014-9
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0014-9&pdf
http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2011-0014-9
Novel small molecules as GSK-3β inhibitors in human neural progenitor cells
2010
Druck-Ausgabe
(DE-627)655211519
Schmöle, Anne-Caroline, 1983 -
urn:nbn:de:gbv:28-diss2011-0014-9
838904981
rakwb
DE-627
120313
68840362X
20240716T042329.0
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