Annexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosis
Patel, Devang
1981-
aut
text
theses
Text
Hochschulschrift
gw
2010
monographic
XA-DE
2010
eng
text/html
application/pdf
Online-Ressource Ill., graph. Darst.
In the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression resulted in impaired phagocytosis and actin flashing. These data revealed that annexin A1 as an important component of opsonic phagocytosis.
vorgelegt von Devang Patel
Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2011
570
42.15
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0019-0
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2011-0019-0&pdf
http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2011-0019-0
Annexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosis
2010
Druck-Ausgabe
(DE-627)644454237
Patel, Devang, 1981 -
urn:nbn:de:gbv:28-diss2011-0019-0
838902895
rakwb
DE-627
120313
688394019
20251224T180134.0
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