Molecular mechanisms controlling the tissue-specific activity of the nutritionally regulated promoter I of the acetyl-CoA carboxylase-α encoding gene in cattle
Shi, Xuanming
1975-
aut
text
theses
Text
Hochschulschrift
gw
2009
monographic
XA-DE
2009
eng
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Online-Ressource Ill., graph. Darst.
We analyzed molecular mechanisms controlling the activity of the nutritionally regulated promoter I (PI) of the bovine acetyl-CoA-carboxylase-alpha gene. PI-activity is driven by NF-Y and C/EBP factors having bound to high affinity sites on the proximal PI. However, both factors may also bind to low affinity sites on the distal PI. From there, they act as repressors of PI. We found that NF-Y may diminish and block C/EBP-beta mediated PI activation, even in trans, through direct factor interaction. Alterations in the concentrations of both factors apparently regulate the tissue specific PI-activity.
by Xuanming Shi
Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2009
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572.574196422
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WC 4460
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42.63
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0184-9
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0184-9&pdf
http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0184-9
http://d-nb.info/1014260035/34
http://rosdok.uni-rostock.de/file/rosdok_derivate_000000004088/Dissertation_Shi_2009.pdf
Molecular mechanisms controlling the tissue-specific activity of the nutritionally regulated promoter I of the acetyl-CoA carboxylase-α encoding gene in cattle
2009
Druck-Ausgabe
(DE-627)612013553
Shi, Xuanming, 1975 -
urn:nbn:de:gbv:28-diss2009-0184-9
837774720
rakwb
DE-627
110420
656766433
20251223T225240.0
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