Die
Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens
ATP8-Gens
Hildebrandt, Anke
1983-
aut
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theses
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Hochschulschrift
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2009
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XA-DE
2009
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We investigated whether a mutation in the ATPase subunit-8 gene exerts effects on the course of endotoxemic acute liver failure in mice. Wildtype and ATP8 mutant mice were challenged with D-galactosamine and E. coli lipopolysaccharide and studied 6 hrs thereafter. Induction of endotoxemic liver failure provoked marked liver damage, a drop of total adenosine nucleotide level and an increased malondialdehyde production. In contrast, ATP levels in livers ATP8 mutants remained significantly higher. As a net result, ATP8 mutant mice showed lower transaminase release and better survival rate.
vorgelegt von Anke Hildebrandt
Rostock, Univ., Med. Fak., Diss., 2010
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http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2010-0091-5
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Die Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens
2009
Druck-Ausgabe
(DE-627)627686192
Hildebrandt, Anke, 1983 -
urn:nbn:de:gbv:28-diss2010-0091-5
669794416
rakwb
DE-627
100701
63043607X
20251223T223443.0
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