Development of a focused chemical library
synthesis of novel bioactive hymenialdisine derivatives
Kaiser, Hanns Martin
1980-
aut
text
theses
Text
Hochschulschrift
gw
2008
monographic
XA-DE
2008
eng
Online-Ressource Ill., graph. Darst.
This dissertation deals with the synthesis of novel bioactive derivatives of the natural occurring hymenialdisine. As a part of this project, a solvent-free, efficient, and easy to handle diversification strategy for annulated hymenialdisine-type bisindoles was developed. A C-C bond-formation reaction on activated silica under mild reaction conditions starting from aziridines, epoxides or hydroxyl compounds is the key technology. The versatility of different aziridines as key building blocks was demonstrated with H-, O-, and N-nucleophiles in a diversity oriented synthesis to build up a focused chemical library. Furthermore, novel transition metal mediated introduction and transformation of functional-groups for potential application in the synthesis of novel drug candidates were developed.
vorgelegt von Hanns Martin Kaiser
Enth. Beitr. aus versch. Ztschr
Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2008
540 610
35.00
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2008-0124-1
http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2008-0124-1&pdf
http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2008-0124-1
Development of a focused chemical library
2008
Druck-Ausgabe
(DE-627)587910445
Kaiser, Hanns Martin, 1980 -
urn:nbn:de:gbv:28-diss2008-0124-1
314799003
rakwb
DE-627
090121
589754890
20240710T003445.0
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