Loss-Of HSPB8 leads to prolonged stress granules disassembly via impaired CASA-complex ultimately causing FUS-aggregation
Heat shock protein beta-8 chaperone-assisted selective autophagy fused in sarcoma
chaperone-assisted selective autophagy-complex fused in sarcoma-aggregation
Saleem, Kanza
1991-
VerfasserIn
aut
Hermann, Andreas
1978-
AkademischeR BetreuerIn
dgs
Petri, Susanne
1972-
AkademischeR BetreuerIn
dgs
Kipp, Markus
1978-
AkademischeR BetreuerIn
dgs
Universität Rostock
Grad-verleihende Institution
dgg
Universitätsmedizin Rostock
Grad-verleihende Institution
dgg
text
theses
Text
Hochschulschrift
gw
2023
monographic
XA-DE
Rostock
Universität Rostock
publisher
18.09.2023
Rostock
Universitätsbibliothek Rostock
distributor
eng
ger
application/pdf
1 Online-Ressource (140 Seiten) Illustrationen, Diagramme
Our research sheds light on the collaborative functioning of various chaperone systems within the proteostasis network. Molecular chaperones, including HSP70, and HSP40, and co-chaperones like HSC70, HSP90, and CHIP, are vital in protein quality control and degradation. Dysregulation within these systems, observed in HSPB8 knockout neurons, indicates impaired mechanisms for maintaining cellular proteostasis. This deficiency renders cells vulnerable to stress, resulting in detrimental effects on cellular survival.<eng>
Open Access
Urheberrechtsschutz 1.0
vorgelegt von Kanza Saleem
GutachterInnen: Andreas Hermann (Universitätsmedizin Rostock) ; Susanne Petri (Klinik für Neurologie mit Klinischer Neurophysiologie) ; Markus Kipp (Universitätsmedizin Rostock)
Dissertation Universität Rostock 2024
610
616.8
610
44.90
44.34
44.37
https://purl.uni-rostock.de/rosdok/id00004622
https://doi.org/10.18453/rosdok_id00004622
https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004622-9
https://d-nb.info/1334986673/34
Loss-Of HSPB8 leads to prolonged stress granules disassembly via impaired CASA-complex ultimately causing FUS-aggregation
Rostock : Universität Rostock, 2023
Druck-Ausgabe
(DE-627)1892823349
Saleem, Kanza, 1991 -
urn:nbn:de:gbv:28-rosdok_id00004622-9
10.18453/rosdok_id00004622
1443181923
rda
DE-627
240701
189282163X
20251227T180652.0
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