Elucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combination
Lupu, Loredana-Mirela
1992-
VerfasserIn
aut
Tiedge, Markus
1963-
AkademischeR BetreuerIn
dgs
Glocker, Michael
1960-
AkademischeR BetreuerIn
dgs
Przybylski, Michael
1948-2023
AkademischeR BetreuerIn
dgs
Universität Rostock
Grad-verleihende Institution
dgg
Universitätsmedizin Rostock
Grad-verleihende Institution
dgg
text
theses
Text
Hochschulschrift
gw
2022
monographic
XA-DE
Rostock
Universität Rostock
publisher
2022
Rostock
Universitätsbibliothek Rostock
distributor
eng
application/pdf
1 Online-Ressource (getrennte Zählung) Illustrationen, Diagramme
The PROTEX-SPR-MS method has unveiled several epitopes with promising medical applications, including an epitope peptide suitable for antibody removal in Fabry's disease. Additionally, an epitope conducive to early heart muscle injury diagnosis was identified and characterized.Furthermore, PROTEX-SPR-MS has been employed to study two distinct single-stranded DNA aptamers interacting with a tumor biomarker protein. This analysis has revealed that aptamers have remarkably similar affinity and epitope binding to antibodies, suggesting their potential utility in medical applications.<eng>
Open Access
Urheberrechtsschutz 1.0
vorgelegt von Loredana-Mirela Lupu
Enthält Zeitschriftenartikel
GutachterInnen: Markus Tiedge (Institut für Medizinische Biochemie und Molekularbiologie) ; Michael O. Glocker (Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung) ; Michael Przybylski (AffyMSLifeChem)
Dissertation Universität Rostock 2023 Kumulative Dissertation
500
615.19
610
35.78
42.13
https://purl.uni-rostock.de/rosdok/id00004458
https://doi.org/10.18453/rosdok_id00004458
https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004458-6
https://d-nb.info/1309753776/34
Elucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combination
Rostock : Universität Rostock, 2022
Druck-Ausgabe
(DE-627)1869705734
Lupu, Loredana-Mirela, 1992 -
urn:nbn:de:gbv:28-rosdok_id00004458-6
10.18453/rosdok_id00004458
1408381628
rda
DE-627
231108
1869704800
20251226T212802.0
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