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    <title>Distress analysis of mice used for translational research</title>
    <subTitle>reflection of a surgeon on animal welfare</subTitle>
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  <abstract type="Summary">The assessment and improvement of animal welfare is not only an ethical requirement, but also a guarantee of efficient and high quality translational research. In recent years, sophisticated animal models were created to study human diseases. However, the assessment of distress in these animal models is scarce. In order to provide a solid basis for optimizing animal welfare in future studies, body weight, burrowing, nesting activity, faecal corticosterone metabolites (FCMs), and distress scores were analyzed in several animal models.&lt;eng&gt;</abstract>
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  <note type="statement of responsibility">vorgelegt von Wentao Xie</note>
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  <note>Publications: Wentao Xie, Marcel Kordt, Rupert Palme, Eberhard Grambow, Brigitte Vollmar, Dietmar Zechner. Diagnostic Ability of Methods Depicting Distress of Tumor-Bearing Mice. Animals. 2021;1:2155. Wentao Xie, Rupert Palme, Clemens Schafmayer, Dietmar Zechner, Brigitte Vollmar, Eberhard Grambow. Distress Analysis of Mice with Cervical Arteriovenous Fistulas. Animals. 2021;11:3051. WentaoXie, Matthias Lorenz, Friederike Poosch, Rupert Palme, Dietmar Zechner, Brigitte Vollmar, Eberhard Grambow, Daniel Strüder. 3D-printed lightweight dorsal skin fold chambers from PEEK reduce chamber-related animal distress. Sci Rep. 2022;12:11599</note>
  <note>GutachterInnen: Dietmar Zechner (Universitätsmedizin Rostock) ; Hugo Murua Escobar (Universitätsmedizin Rostock) ; Ute Lindauer (RWTH Aachen)</note>
  <note type="thesis">Dissertation Universität Rostock 2023 Kumulative Dissertation</note>
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