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    <title>Neue Ansätze für die funktionale Analyse von IGF-Effekten in vivo und vitro</title>
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  <abstract type="Summary">Die Mitglieder des IGF-Systems regulieren das Wachstum auf unterschiedlichen Ebenen. In der Vergangenheit zog man zur Beschreibung des IGF-Systems überwiegend absolute Konzentrationen einzelner Hormone heran. Nach aktuellem Verständnis rückt für die Beschreibung des IGF-Systems jedoch die Analyse der biologischen Aktivität in den Vordergrund. In der Arbeit wird die Interaktion mehrerer Faktoren zur Beschreibung der Wachstumsregulation in auf Wachstum selektierten und in transgenen Mauslinien stärker berücksichtigt. Des Weiteren wird ein Bioassay für die In-vitro-Analyse mit vorgestellt.&lt;ger&gt;</abstract>
  <abstract type="Summary">The members of the IGF system regulate growth at different levels. In the past, absolute concentrations of individual hormones were mainly used to describe the IGF system. According to current understanding, however, the analysis of the biological activity comes to the foreground for the description of the IGF system. In this work, the interaction of several factors is given greater consideration for the description of growth regulation in mouse lines selected for growth and in transgenic mouse lines. Furthermore, a bio-assay for in vitro analysis is presented.&lt;eng&gt;</abstract>
  <note type="statement of responsibility">vorgelegt von Michael Walz</note>
  <note>Enthält Zeitschriftenartikel</note>
  <note>GutachterInnen: Holger S. Willenberg (Universitätsmedizin Rostock, Universität Rostock) ; Michael Lalk (Institut für Biochemie, Universität Greifswald) ; Andreas Höflich (Institut für Genombiologie, Forschungsinstitut für Nutztierbiologie (FBN))</note>
  <note type="thesis">Dissertation Universität Rostock 2022 Kumulative Dissertation</note>
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      <title>Neue Ansätze für die funktionale Analyse von IGF-Effekten in vivo und vitro</title>
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