Defective myelination and its relative mechanism in Niemann-Pick type C disease
Yang, Fan
1986-
VerfasserIn
aut
Luo, Jiankai
1963-
AkademischeR BetreuerIn
dgs
Köhling, Rüdiger
1966-
AkademischeR BetreuerIn
dgs
Pufe, Thomas
1972-
AkademischeR BetreuerIn
dgs
Universität Rostock
Grad-verleihende Institution
dgg
Universitätsmedizin Rostock
Grad-verleihende Institution
dgg
text
theses
Text
Hochschulschrift
gw
2019
monographic
XA-DE
Rostock
Universität
publisher
2019
Rostock
Universitätsbibliothek
distributor
eng
1 Online-Ressource
Niemann-Pick type C (NPC) disease is caused by mutations in npc1 or npc2 gene. In this study, we found the maturation of NPC1-/- oligodendrocytes was significantly inhibited, the myelin-related transcription factors Olig1 and Olig2 were downregulated and the nucleocytoplasmic transport of p57Kip2 was inhibited in NPC1-/- oligodendrocytes. Treatment of lovastatin reduced accumulation of cholesterol in the late endosomal and lysosomal, increased the expression of Olig1 and Olig2, recovered the nucleocytoplasmic transport of p57Kip2, and restored the maturation of NPC1-/- oligodendrocytes.<eng>
vorgelegt von Fan Yang
GutachterInnen: Jiankai Luo (Universitätsmedizin Rostock) ; Rüdiger Köhling (Universitätsmedizin Rostock) ; Thomas Pufe (Universitätsklinikum Aachen)
Dissertation Universität Rostock 2022
500
570
610
616.8
610
YC 7417
44.37
44.77
http://purl.uni-rostock.de/rosdok/id00003713
https://doi.org/10.18453/rosdok_id00003713
https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003713-9
https://d-nb.info/1293537683/34
Defective myelination and its relative mechanism in Niemann-Pick type C disease
Rostock, 2022
Druckausgabe
(DE-627)1808047729
Yang, Fan, 1986 -
urn:nbn:de:gbv:28-rosdok_id00003713-9
10.18453/rosdok_id00003713
1331713566
rda
DE-627
220623
1807555275
20251226T202645.0
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(Revision 1.174 20250328)
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