Modeling perspective on translatability of deep brain stimulation mechanism for treating Parkinsonian motor symptoms in rodent and human
Butenko, Konstantin
1994-
VerfasserIn
aut
Rienen, Ursula van
1957-
AkademischeR BetreuerIn
dgs
Köhling, Rüdiger
1966-
AkademischeR BetreuerIn
dgs
Lowery, Madeleine
AkademischeR BetreuerIn
dgs
Universität Rostock
Grad-verleihende Institution
dgg
Universität Rostock
Fakultät für Informatik und Elektrotechnik
Grad-verleihende Institution
dgg
text
theses
Text
Hochschulschrift
gw
2021
monographic
XA-DE
Rostock
Universität
publisher
2021
Rostock
Universitätsbibliothek
distributor
eng
1 Online-Ressource
Deep brain stimulation is an established treatment for Parkinson’s disease (PD). However, to advance its effectiveness, researchers need to gain a better understanding of the action mechanism by means of in vivo and in silico studies. This thesis presents neural activation patterns theoretically beneficial for motor improvement in PD and analyzes their theoretical reproducibility in a rat brain. Besides, it elucidates biophysical and computational problems to be addressed in order to optimize animal studies and avoid misconceptions when transferring experimental findings to clinical trials.<eng>
vorgelegt von Konstantin Butenko
GutachterInnen: Ursula van Rienen (Universität Rostock) ; Rüdiger Köhling (Universitätsmedizin Rostock) ; Madeleine Lowery (University College Dublin)
Dissertation Universität Rostock 2022
620
616.8
610
http://purl.uni-rostock.de/rosdok/id00003623
https://doi.org/10.18453/rosdok_id00003623
https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003623-9
https://d-nb.info/1293537381/34
Modeling perspective on translatability of deep brain stimulation mechanism for treating Parkinsonian motor symptoms in rodent and human
Rostock, 2021
Druckausgabe
(DE-627)1800251807
Butenko, Konstantin, 1994 -
urn:nbn:de:gbv:28-rosdok_id00003623-9
10.18453/rosdok_id00003623
1312334517
rda
DE-627
220421
1799953491
20251226T201958.0
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