Transcription factor properties of ZNF746 and ZNF777 with focus on their domains of unknown function 3669 (DUF3669)
Al Chiblak, Mohannad
1982-
VerfasserIn
aut
Tiedge, Markus
1963-
AkademischeR BetreuerIn
dgs
Thiesen, Hans-Jürgen
1956-
AkademischeR BetreuerIn
dgs
Sina, Christian
1976-
AkademischeR BetreuerIn
dgs
Universität Rostock
Grad-verleihende Institution
dgg
Universitätsmedizin Rostock
Grad-verleihende Institution
dgg
text
theses
Text
Hochschulschrift
gw
2020
monographic
XA-DE
Rostock
Universität
publisher
2020
Rostock
Universitätsbibliothek
distributor
eng
1 Online-Ressource
This study evaluates the repression activities of two DUF3669-containing KRAB-ZNF proteins; ZNF746 and ZNF777 in addition to the oligomerizing ability of their domain of unknown function (DUF3669). A new domain model for DUF3669 has been established in this study. DUF3669 as an oligomerizing domain was confirmed in our study. Our data revealed the adding functionalities for the repression activities of ZNF746; DUF3669 as an oligomerizing domain might recruit other DUF3669-KRAB-ZNF proteins and the SUMOylation might stabilize the repression complex and directly recruit chromatin modifiers.<eng>
vorgelegt von Mohannadd Al Chiblak
GutachterInnen: Markus Tiedge (Universitätsmedizin Rostock, Institut für Medizinische Biochemie und Molekularbiologie) ; Hans-Jürgen Thiesen (Universitätsmedizin Rostock, Institut für Immunologie) ; Christian Sina (Universitätsklinikum Schleswig-Holstein, Institut für Ernährungsmedizin)
Dissertation Universität Rostock 2020
570
570
WG 1940
42.13
http://purl.uni-rostock.de/rosdok/id00002800
https://doi.org/10.18453/rosdok_id00002800
https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00002800-3
https://d-nb.info/1293661309/34
Transcription factor properties of ZNF746 and ZNF777 with focus on their domains of unknown function 3669 (DUF3669)
Rostock, 2020
Druck-Ausgabe
(DE-627)1738548317
Al Chiblak, Mohannad, 1982 -
urn:nbn:de:gbv:28-rosdok_id00002800-3
10.18453/rosdok_id00002800
1226315138
rda
DE-627
201109
1738232549
20251226T190459.0
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