Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cells
role of the anti-oxidative enzyme heme oxygenase-1
Schwartz, Margit
1986-
VerfasserIn
aut
Hinz, Burkhard
1967-
AkademischeR BetreuerIn
dgs
Rauch, Bernhard
AkademischeR BetreuerIn
dgs
Kraft, Karin
1952-
AkademischeR BetreuerIn
dgs
Universität Rostock
Grad-verleihende Institution
dgg
Universitätsmedizin Rostock
Grad-verleihende Institution
dgg
text
theses
Text
Hochschulschrift
gw
2018
monographic
XA-DE
Rostock
Universität
publisher
2018
Rostock
Universitätsbibliothek
distributor
eng
1 Online-Ressource
Excessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects via an HO-1-independent mechanism.<eng>
vorgelegt von Margit Schwartz
GutachterInnen: Burkhard Hinz (Universitätsmedizin Rostock, Institut für Pharmakologie und Toxikologie) ; Bernhard Rauch (Universitätsmedizin Greifswald, Institut für Pharmakologie, Abt. Allg. Pharmakologie) ; Karin Kraft (Universitätsmedizin Rostock, Zentrum für Innnere Medizin, Lehrstuhl für Naturheilkunde)
Dissertation Universität Rostock 2019
570
610
612.01
610
XI 5104
44.38
http://purl.uni-rostock.de/rosdok/id00002522
https://doi.org/10.18453/rosdok_id00002522
https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00002522-0
https://d-nb.info/1293657557/34
Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cells
Rostock, 2018
Druck-Ausgabe
(DE-627)1671834267
Schwartz, Margit, 1986 -
urn:nbn:de:gbv:28-rosdok_id00002522-0
10.18453/rosdok_id00002522
1135661028
rda
DE-627
190821
167175865X
20251226T180101.0
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