%0 Book
%T Total Synthesis of (±)-Maoecrystal V
%A Gong, Jianxian
%S Springer Theses, Recognizing Outstanding Ph.D. Research
%D 2014
%C Berlin, Heidelberg
%@ 9783642543043
%G English
%F 1653673664
%O by Jianxian Gong
%O "Doctoral thesis accepted by Peking Universtiy, Beijing, China
%O Includes bibliographical references
%X In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereoselective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures
%L 547
%K Chemistry
%K Chemistry, Organic
%K Biochemistry
%K Catalysis
%9 Text
%R 10.1007/978-3-642-54304-3
%U https://swbplus.bsz-bw.de/bsz402417747cov.jpg
%U https://doi.org/10.1007/978-3-642-54304-3