%0 Book
%T Exploring the spatio-temporal dynamics of lipid rafts and their role in signal transduction: a modeling and simulation approach
%A Haack, Fiete
%D 2015
%C Rostock
%C Universität Rostock
%G English
%F 865456275
%O vorgelegt von: Fiete Haack aus Rostock
%O Dissertation Universität Rostock 2016
%X The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach.<eng>
%L 004
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2016-0080-1