%0 Book
%T MicroRNA-based stem cell modifications using magnetic transfection complexes: a non-viral approach towards cardiac regeneration = MikroRNA-basierte Stammzellmodifikationen mittels magnetischer Transfektionskomplexe : ein nicht-viraler Ansatz für die kardiale Regeneration = MikroRNA-basierte Stammzellmodifikationen mittels magnetischer Transfektionskomplexe
%A Schade, Anna
%D 2015
%C Rostock
%C Universität Rostock
%G English
%F 856304654
%O submitted by: Anna Schade (geborene Sponholz), from Rostock
%O Dissertation Universität Rostock 2015
%X Regenerative properties of human mesenchymal stem cells (hMSC) can be enhanced by genetic modifications. Thus we aimed to develop a magnetic non-viral vector for microRNA (miR) delivery in freshly isolated hMSCs. miR/PEI/MNP transfection showed a better long term performance compared to miR/PEI transfection. Moreover magnetically modified hMSCs could be guided by an external magnet contributing to enhanced cell engraftment. Conclusively a magnetic non-viral carrier for efficient miR delivery in freshly isolated hMSCs was developed allowing specific control of stem cells and magnetic targeting.<eng>
%L 610
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2015-0234-1