%0 Book
%T Gene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancer
%A Salem, Tareq
%D 2014
%G English
%F 805590951
%O submitted by Tareq Salem
%O Rostock, Univ., Med. Fak., Diss., 2014
%X This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.
%L 610
%9 theses
%9 Text
%9 Hochschulschrift
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0174-3
%U http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0174-3&pdf
%U http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0174-3